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Graphene quantum dots alleviate ROS-mediated gastric damage
Preety Choudhary1, Sushama Biswas2, Noufal Kandoth3
1CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata 700 032, India.
Iscience
|April 1, 2022
Summary
Graphene quantum dots (GQDs) effectively scavenge reactive oxygen species (ROS) and reduce oxidative stress. This study demonstrates GQDs
Area of Science:
- Nanomaterials Science
- Biomedical Engineering
- Gastroenterology
Background:
- The gastrointestinal tract is a primary site for reactive oxygen species (ROS) generation.
- Physiological ROS levels maintain gut integrity, but excessive ROS causes oxidative damage and disorders.
- Graphene quantum dots (GQDs) are nanomaterials known for antioxidant properties.
Purpose of the Study:
- To investigate the efficacy of Graphene quantum dots (GQDs) in scavenging ROS.
- To evaluate the therapeutic potential of GQDs in mitigating stress-induced gastric ulcers.
- To elucidate the molecular mechanisms underlying GQD-mediated gastroprotection.
Main Methods:
- In vitro assessment of ROS scavenging activity of GQDs.
- In vivo models of stress-induced gastric ulcers.
- Analysis of molecular markers including MMP-9, caspase activity, Bax, and BCL2 expression.
Main Results:
- GQDs demonstrated high efficiency in scavenging ROS.
- GQDs significantly suppressed stress-induced gastric ulcers.
- GQD treatment modulated the MMP-9 pathway, reduced inflammation, and altered apoptosis-related protein expression (Bax, BCL2).
Conclusions:
- Graphene quantum dots (GQDs) exhibit potent antioxidant and anti-ulcer effects.
- GQDs protect against gastric ulcers by targeting the MMP-9 pathway and reducing oxidative stress.
- GQDs represent a promising therapeutic agent for gastrointestinal disorders associated with oxidative stress.
