Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.3K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.3K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.3K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.3K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

313
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
313
Menopause01:28

Menopause

545
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
545
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

722
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
722
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

1.1K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between long-term exposure to environmental carbon monoxide and the prevalence of thyroid disorders in China: a nationwide study.

Journal of endocrinological investigation·2026
Same author

Chronic Iodine Excess and Aging Synergistically Impact Thyrotropin Elevation: A Prospective 20-Year Follow-Up Study in China.

Thyroid : official journal of the American Thyroid Association·2026
Same author

Predicting dysthyroid optic neuropathy in moderate-to-severe thyroid eye disease: a clinically applicable nomogram.

European thyroid journal·2025
Same author

The Effects of Counter-Ions on Peptide Structure, Activity, and Applications.

Biomolecules·2025
Same author

Antimicrobial Peptides for Skin Wound Healing.

Biomolecules·2025
Same author

Effects of Maternal Iodine Deficiency in Women with Mild Thyroid Dysfunction During Early Pregnancy on Mental and Motor Growth of Their Offspring During Levothyroxine Treatment.

Biological trace element research·2025

Related Experiment Video

Updated: Sep 28, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

999

Menopausal Impact on the Association Between Thyroid Dysfunction and Lipid Profiles: A Cross-Sectional Study.

Yutong Han1, Chuyuan Wang1, Lihui Zhang2

  • 1Department of Endocrinology and Metabolism, The Institute of Endocrinology, National Health Commission (NHC) Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Frontiers in Endocrinology
|April 1, 2022
PubMed
Summary

Thyroid dysfunction significantly impacts blood lipid levels, increasing risks for hypertriglyceridemia in hypothyroidism and hyper-low-density lipoprotein cholesterolemia in subclinical hypothyroidism. Hyperthyroidism shows mixed effects on cholesterol levels.

Keywords:
blood lipidsdyslipidemiahypercholesterolemiamenopausesubclinical hypothyroidismthyroid function

More Related Videos

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.3K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K

Related Experiment Videos

Last Updated: Sep 28, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

999
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.3K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Dyslipidemia and thyroid dysfunction are prevalent conditions and significant cardiovascular disease risk factors.
  • The precise relationship between thyroid function and blood lipid profiles remains a subject of ongoing research and debate.
  • Understanding these connections is crucial for comprehensive cardiovascular risk assessment.

Purpose of the Study:

  • To investigate the associations between various thyroid function statuses and blood lipid profiles in a large adult population.
  • To identify specific lipid abnormalities linked to hypothyroidism, subclinical hypothyroidism, and hyperthyroidism.
  • To explore potential influences of menopausal status on these relationships.

Main Methods:

  • A cross-sectional study utilizing data from the TIDE survey, including 10,747 adult participants.
  • Participants were categorized into hypothyroidism, subclinical hypothyroidism, hyperthyroidism, subclinical hyperthyroidism, and control groups based on thyroid function.
  • Logistic regression models were employed to analyze the risk of dyslipidemia, considering menopausal status.

Main Results:

  • Hypothyroidism was associated with an increased risk of hypertriglyceridemia.
  • Subclinical hypothyroidism correlated with higher risks of hypertriglyceridemia and hyper-low-density lipoprotein cholesterolemia.
  • Hyperthyroidism showed a reduced risk of hypercholesterolemia and hyper-low-density lipoprotein cholesterolemia but an increased risk of low-high density lipoprotein cholesterolemia.

Conclusions:

  • Abnormal thyroid function significantly influences blood lipid levels, contributing to dyslipidemia.
  • The observed effects of thyroid dysfunction on blood lipids are particularly relevant in the context of female menopause.
  • These findings highlight the importance of assessing thyroid function in patients with lipid abnormalities.