Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

822
The pathophysiology of pneumonia involves the following steps:
822
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

408
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
408
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.2K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.8K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.8K
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

368
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
368
Pneumothorax-I01:26

Pneumothorax-I

431
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
431

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TikTok as a platform for visual health communication: designing and evaluating short-form videos.

Journal of visual communication in medicine·2026
Same author

Type 2 diabetes genetics in 125,000 admixed adults from Mexico City.

medRxiv : the preprint server for health sciences·2026
Same author

Safety of very low LDL-cholesterol: Ten common concerns, misconceptions, and evidence-based clarifications.

Atherosclerosis·2026
Same author

Zinc deficiency and sarcopenia define a metabolic frailty phenotype predicting hepatic encephalopathy and early mortality in cirrhosis.

Metabolic brain disease·2026
Same author

Global survey of genetic testing methods for familial hypercholesterolemia. A study and recommendations from the EAS FHSC registry.

European journal of preventive cardiology·2026
Same author

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.

The lancet. Diabetes & endocrinology·2026

Related Experiment Video

Updated: Sep 28, 2025

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
07:18

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

Published on: April 14, 2023

1.9K

Physiological Network Is Disrupted in Severe COVID-19.

Antonio Barajas-Martínez1,2,3, Roopa Mehta4, Elizabeth Ibarra-Coronado5

  • 1Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Frontiers in Physiology
|April 1, 2022
PubMed
Summary

COVID-19 impacts physiological regulation, with young men facing severe outcomes. This study reveals distinct physiological network disruptions, particularly anthropometric, metabolic, inflammatory, and pulmonary clusters, in deceased young males.

Keywords:
homeostasisnetwork physiologypro-inflammatory statesevere COVID-19sex differences

More Related Videos

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

3.6K
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

2.9K

Related Experiment Videos

Last Updated: Sep 28, 2025

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
07:18

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

Published on: April 14, 2023

1.9K
An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

3.6K
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

2.9K

Area of Science:

  • Physiology
  • Immunology
  • Network Science

Background:

  • The human body maintains homeostasis through complex physiological regulation systems.
  • SARS-COV-2 infection challenges the immune system, with elderly individuals and men exhibiting higher vulnerability to severe COVID-19.
  • Mexico reports a notable number of infected young men, prompting investigation into specific risk factors.

Purpose of the Study:

  • To investigate differences in physiological variable relationships between elderly individuals/men and those associated with fatal outcomes in young men.
  • To analyze physiological network characteristics in COVID-19 patients stratified by outcome, age, and sex.

Main Methods:

  • Utilized a database of 748 moderate-to-severe COVID-19 patients (471 men, 277 women).
  • Constructed physiological networks using 67 variables (vital signs, anthropometric, hematic, biochemical, tomographic).
  • Employed descriptive statistics, principal component analysis, and network analysis to examine individual variables and system behavior.

Main Results:

  • Topological network properties, such as the clustering coefficient, were significantly disrupted during disease.
  • Distinct clusters of anthropometric, metabolic, inflammatory, and pulmonary variables characterized the group of deceased young men.

Conclusions:

  • Physiological network analysis reveals specific patterns associated with severe COVID-19 outcomes in young men.
  • Understanding these disruptions can inform targeted interventions for vulnerable populations.