Acute Myocardial Injury Assessed by High-Sensitive Cardiac Troponin Predicting Severe Outcomes and Death in
Falmata Laouan Brem1, Miri Chaymae1, Hammam Rasras1
1Department of Cardiology, 470522Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.
Insights
COVID-19 patients with cardiac injury are older and have more comorbidities. Acute cardiac injury in COVID-19 patients significantly increases the risk of intensive care unit admission and death.
Area of Science:
- Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- Cardiac injury is a known predictor of poor prognosis in COVID-19.
- Risk factors and outcomes associated with cardiac injury in COVID-19 patients require further investigation.
Purpose of the Study:
- To compare demographic characteristics and in-hospital outcomes of COVID-19 patients with and without cardiac injury.
- To determine the prevalence and impact of acute cardiac injury on COVID-19 patient outcomes.
Main Methods:
- Retrospective analysis of 298 COVID-19 patients admitted between October and December 2020.
- Systematic troponin assay measurement on admission for all patients.
- Comparison of clinical, biological data, and in-hospital outcomes between cardiac-injured and non-cardiac-injured groups.
Main Results:
- Cardiac-injured COVID-19 patients were older and had higher rates of hypertension and diabetes.
- Increased incidence of mechanical ventilation, ICU admission, and mortality observed in cardiac-injured patients.
- Cox regression analysis revealed a significantly increased risk of death (HR, 1.620) in cardiac-injured COVID-19 patients.
Conclusions:
- Old age, comorbidities (hypertension, diabetes), and a history of coronary artery disease (CAD) are associated with acute cardiac injury in COVID-19.
- COVID-19 patients with acute cardiac injury face a higher risk of ICU admission and mortality.
Background:
Cardiac injury has been linked to a poor prognosis during COVID-19 disease. Nevertheless, the risk factors associated are yet to be thoroughly investigated.
Objectives:
We sought to compare demographical characteristics and in-hospital outcomes in patients infected by the SARS-CoV-2 with and without cardiac injury, to further investigate the prevalence of acute cardiac injury as well as its impact on their outcomes in COVID-19-patients.
Methods:
We included in a retrospective analysis, all COVID-19 patients admitted between October first and December first, 2020, at the University Hospital Center of Oujda (Morocco) who underwent a troponin assay which was systematically measured on admission. The study population was divided into two groups: cardiac-injured patients and those without cardiac injury. Clinical, biological data and in-hospital outcomes were compared between the two groups.
Results:
298 confirmed COVID-19 cases were included. Our study found that compared to non-cardiac-injured, cardiac-injured patients are older, with higher possibilities of existing comorbidities including hypertension (68 [42.2%] vs 40 [29.2%], P = 0.02), diabetes (81 [50.3%] vs 53 [38.7%] P = 0.044), the need for mechanical ventilation, ICU admission and mortality. A Cox proportional hazards regression analysis shows a significantly increased risk of death among cardiac-injured COVID-19-patients as compared to non-cardiac injured. (HR, 1.620 [CI 95%: 2.562-1.024]).
Conclusion:
Our retrospective cohort found that old age, comorbidities, a previous history of CAD, were significantly associated with acute cardiac injury. COVID-19 patients with acute cardiac injury are at a higher risk of ICU admission, and death.
More Related Videos
07:40Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
Published on: October 10, 2019
04:41Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:30Acute Coronary Syndrome I: Introduction
01:28Acute Coronary Syndrome IV: Interprofessional Care
01:27Myocarditis II: Clinical Features and Diagnostic Tests
01:14Myocarditis III: Medical Management