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Elevated serum homocysteine levels are associated with the development of chronic venous ulcers

Zhenyu Guo1, Xu Li1, Tao Wang1

  • 1Department of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.

Vascular Medicine (London, England)
|April 1, 2022
PubMed

Insights

High homocysteine levels (HHcy) are linked to venous ulcer development in patients with varicose veins. This study found HHcy significantly associated with ulcer formation and progression, suggesting a potential therapeutic target.

Area of Science:

  • Vascular Biology
  • Clinical Medicine
  • Biochemistry

Background:

  • Venous ulceration is a complex condition.
  • The role of hyperhomocysteinemia (HHcy) in venous ulcer development from varicose veins is not well-established.

Purpose of the Study:

  • To investigate the correlation between HHcy and the formation of venous ulcers in patients with primary varicose veins.
  • To explore the underlying mechanisms of HHcy-induced vascular changes.

Main Methods:

  • Retrospective analysis of clinical data from 717 patients (106 with ulcers, 611 without).
  • Multivariate logistic regression and propensity score matching were employed.
  • In vitro experiments assessed HHcy's effect on endothelial cells and vascular smooth muscle cells.

Main Results:

  • A significantly higher prevalence of HHcy was observed in patients with venous ulcers (46.2%) compared to controls (17.5%).
  • HHcy was independently associated with venous ulceration in primary varicose veins (p < 0.001).
  • Experimental data indicated HHcy induces endothelial dysfunction and vascular smooth muscle cell phenotypic switching.

Conclusions:

  • Clinical and experimental evidence strongly implicates HHcy as a contributing factor in venous ulcer development.
  • Further research is warranted to evaluate HHcy-lowering therapies for preventing venous ulcers in varicose vein patients.
Abstract

Keywords:
hyperhomocysteinemiavaricose veinsvenous ulceration

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