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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Pharmacological management of severe plaque psoriasis in patients with cardiovascular disease

Stefano Piaserico1, Francesco Messina1

  • 1Department of Medicine, Dermatology Unit, University of Padua, Padua, Italy.

Expert Opinion on Pharmacotherapy
|April 1, 2022
PubMed

Insights

Psoriasis patients face higher cardiovascular disease risks due to inflammation and risk factors. Careful consideration of systemic treatments is crucial for managing both psoriasis and heart conditions.

Area of Science:

  • Dermatology
  • Cardiology
  • Pharmacology

Background:

  • Psoriasis is independently associated with increased cardiovascular disease (CVD) risk, including myocardial infarction, heart failure, and arrhythmia.
  • Chronic inflammation in psoriasis contributes to CVD through mechanisms like atherosclerosis, microvascular dysfunction, and myocardial fibrosis.
  • Psoriasis management requires careful consideration of traditional CVD risk factors and the inflammatory component.

Purpose of the Study:

  • To review the pharmacological management of severe plaque psoriasis in patients with co-existing cardiovascular disease.
  • To provide expert opinion and future perspectives on balancing psoriasis treatment with cardiovascular health.

Main Methods:

  • Review of current literature on psoriasis and cardiovascular comorbidities.
  • Expert opinion on the pharmacological management strategies.
  • Discussion of the pros and cons of systemic treatments in patients with CVD.

Main Results:

  • Systemic inflammation in psoriasis is a significant contributor to cardiovascular risk.
  • Anti-inflammatory treatments may offer dual benefits for psoriasis and CVD prevention.
  • Some psoriasis treatments may pose risks to the cardiovascular system, necessitating cautious assessment.

Conclusions:

  • The enhanced cardiovascular risk in psoriasis patients necessitates integrated management approaches.
  • Long-term clinical trials are needed to confirm the cardiovascular benefits of psoriasis treatments.
  • Individualized treatment strategies are essential, weighing the risks and benefits of systemic therapies.
Abstract

Keywords:
Psoriasisbiologicscardiovascular diseaseheartheart failuremyocardial infarction

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