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Asthma remission: what is it and how can it be achieved?
Dennis Thomas1, Vanessa M McDonald1,2, Ian D Pavord3
1Priority Research Centre for Healthy Lungs, College of Health, Medicine and Wellbeing, University of Newcastle, Hunter Medical Research Institute, Newcastle, Australia.
The European Respiratory Journal
|April 1, 2022
Summary
Asthma remission, a state of significant symptom control, is achievable but distinct from a cure. Research explores its predictors and potential to become a treatment goal.
Area of Science:
- Pulmonology and Respiratory Medicine
- Clinical Immunology
Background:
- Current asthma management prioritizes symptom and exacerbation control over remission.
- Asthma remission signifies a high level of disease control, including symptom absence and normalized lung function, but may not resolve underlying pathology.
Approach:
- This review synthesizes current definitions, prevalence, predictors, and pathophysiology of asthma remission.
- It examines the potential for achieving remission with existing therapies and identifies future research directions.
Key Points:
- Asthma remission is characterized by symptom absence, no exacerbations, and optimized lung function, with or without treatment.
- Prevalence varies widely (2-52%), influenced by factors like asthma severity, lung function, age, and smoking status.
- Persistent underlying pathology can lead to relapse, differentiating symptomatic remission from complete remission.
Conclusions:
- While not a cure, asthma remission is a valuable therapeutic concept.
- Current add-on therapies like biologics show potential for achieving remission in subsets of patients.
- Future research should investigate treatment-induced remission and consider it as a therapeutic endpoint.
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