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Published on: June 2, 2014
Association between patent foramen ovale and migraine without aura: a community-based cross-sectional study in China
Yusha Tang1, Anjiao Peng1, Bo Peng2
1Department of Neurology, Sichuan University West China Hospital, Chengdu, China.
Objectives:
To assess the influence of patent foramen ovale (PFO) on the prevalence of migraine without aura based on propensity score-matched samples in Southwest China.
Design:
Propensity-matched cross-sectional study.
Participants:
Residents over 20 years of age were recruited from 15 communities of Western China from July 2020 to October 2020. A total of 3741 residents having accepted to undergo contrast-transthoracic echocardiography and a standard structured questionnaire was assessed for the relationship between PFO and migraine without aura.
Primary And Secondary Outcome Measures:
The primary outcome measures were the prevalence of migraine without aura across different degrees of right-left shunts.
Results:
A total of 3741 participants were included. Among them, 881 participants were diagnosed with PFO. The prevalence of migraine without aura in the PFO group was 12.83%, significantly higher than the other group (7.83%, p<0.0001). Analyses of the matched samples showed that the presence of a PFO increased the morbidity risk of migraine without aura (p < 0.001; OR=1.71, 95% CI 1.19 to 2.47).
Conclusion:
This community-based cross-sectional study pointed to a strong association between PFO and migraine without aura, especially when the shunt is large.
Trial Registration Number:
ChiCTR1900024623.
