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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Relationship between periodontitis and psoriasis: A two-sample Mendelian randomization study.

Hansjörg Baurecht1, Dennis Freuer2, Christine Welker1

  • 1Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

Journal of Clinical Periodontology
|April 1, 2022
PubMed
Summary
This summary is machine-generated.

This study used Mendelian randomization to investigate the causal link between periodontitis and psoriasis. Findings indicate no significant bi-directional association, suggesting neither condition influences the other.

Keywords:
Mendelian randomizationepidemiologyperiodontitispsoriasis

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Area of Science:

  • Genetics
  • Periodontology
  • Dermatology

Background:

  • Observational studies suggest a link between periodontitis and psoriasis.
  • However, these studies are limited by reverse causation and confounding factors.
  • Causal inference requires robust methodologies to establish directionality.

Purpose of the Study:

  • To comprehensively assess the potential bi-directional causal association between periodontitis and psoriasis.
  • To overcome limitations of observational studies using Mendelian randomization.
  • To clarify the etiological relationship between these two conditions.

Main Methods:

  • Employed Mendelian randomization (MR) using genetic instruments from large genome-wide association studies.
  • Utilized European descent cohorts for periodontitis (17,353 cases, 28,210 controls) and psoriasis (13,229 cases, 21,543 controls).
  • Applied Causal Analysis Using Summary Effect (CAUSE) and inverse variance-weighted (IVW) MR analyses, with pleiotropy-robust methods for sensitivity analysis.

Main Results:

  • No evidence of periodontitis influencing psoriasis was found (CAUSE OR=1.00, p=1.00; IVW OR=1.02, p=0.6247).
  • No evidence of psoriasis influencing periodontitis was found (CAUSE OR=1.01, p=0.5135; IVW OR=1.00, p=0.7070).
  • Sensitivity analyses using pleiotropy-robust methods corroborated the null findings, with ORs near 1 and p-values > 0.59.

Conclusions:

  • Mendelian randomization analyses did not support a causal effect of periodontitis on psoriasis.
  • Similarly, no evidence was found to support a causal effect of psoriasis on periodontitis.
  • The study concludes no bi-directional causal relationship between periodontitis and psoriasis within its limitations.