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Updated: Sep 28, 2025
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Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
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Obesity-related glomerulopathy: Current approaches and future perspectives
José Ignacio Martínez-Montoro1,2,3, Enrique Morales4,5,6, Isabel Cornejo-Pareja1,2,3,7
1Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain.
Summary
Obesity-related glomerulopathy (ORG) is a growing kidney disease linked to obesity. Early diagnosis and interventions like weight loss and specific medications show promise for managing ORG and preventing kidney failure.
Area of Science:
- Nephrology
- Endocrinology
- Metabolic Diseases
Background:
- Obesity-related glomerulopathy (ORG) is a silent kidney disease with increasing incidence.
- ORG is linked to severe outcomes like chronic kidney disease, end-stage renal disease (ESRD), and mortality.
- Pathogenesis involves hemodynamic changes, RAAS overactivation, insulin resistance, inflammation, and ectopic lipid accumulation.
Purpose of the Study:
- To review current approaches and future perspectives in the care and treatment of ORG.
- To highlight emerging diagnostic tools and therapeutic strategies for ORG.
Main Methods:
- Review of current literature on ORG pathogenesis, diagnosis, and treatment.
- Discussion of novel biomarkers, imaging techniques, and pharmacological interventions.
- Analysis of the role of weight loss, RAAS blockade, SGLT2 inhibitors, and GLP-1 receptor agonists.
Main Results:
- Albuminuria is a common but not definitive marker for ORG.
- Emerging biomarkers, proteomics, metabolomics, and renal imaging offer potential for earlier diagnosis.
- Weight loss interventions show effectiveness, but require large-scale trials.
- RAAS blockade provides renoprotection, yet ESRD progression occurs in a significant proportion.
- SGLT2 inhibitors and GLP-1 receptor agonists present potential therapeutic benefits.
Conclusions:
- ORG is a significant health concern driven by the obesity epidemic.
- Multifaceted approaches including lifestyle changes and targeted therapies are crucial for ORG management.
- Further research is needed to optimize treatment strategies and improve outcomes for patients with ORG.
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