Related Experiment Video
Updated: Sep 28, 2025
10:42
Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
Published on: November 19, 2016
7.7K
Aeroallergens in Atopic Dermatitis and Chronic Urticaria
Albert C Chong1, Won Jong Chwa2, Peck Y Ong3,4
1Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Current Allergy and Asthma Reports
|April 1, 2022
Summary
Aeroallergens are confirmed triggers for atopic dermatitis and emerging triggers for chronic urticaria. Management focuses on avoidance, with immunotherapy needing further study.
Area of Science:
- Dermatology
- Allergology
- Immunology
Background:
- Aeroallergens are known asthma and allergic rhinitis triggers.
- Their role in atopic dermatitis and chronic urticaria is debated.
Purpose of the Study:
- Review pathophysiology and clinical evidence of aeroallergens in allergic skin diseases.
- Summarize current evaluation and management strategies.
Main Methods:
- Review of existing literature on aeroallergen triggers in atopic dermatitis and chronic urticaria.
- Analysis of proposed mechanisms and clinical evidence.
Main Results:
- Aeroallergens clearly trigger atopic dermatitis via skin contact.
- Emerging evidence suggests aeroallergens trigger chronic urticaria.
- Mechanisms involve skin barrier crossing, neuronal activation, and mast cell degranulation.
- Sensitization is linked to chronic urticaria; avoidance is suggested.
Conclusions:
- Aeroallergens play a significant role in atopic dermatitis and increasingly in chronic urticaria.
- Diagnosis involves skin prick or IgE testing.
- Management emphasizes avoidance; immunotherapy efficacy requires more research.
Related Concept Videos
02:06Allergic Reactions
29.0K
Overview
29.0K
01:20Asthma: Pathogenesis and Management
772
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
772
01:26Asthma-II: Pathophysiology and Classification
3.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.0K
01:27Allergic Drug Reactions
1.0K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.0K
01:19Antiasthma Drugs: Leukotriene Modifiers
623
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
623
01:30Hypersensitivities
1.1K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
1.1K