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Light-Controlled Fermentations for Microbial Chemical and Protein Production

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Light-Sensitive Lactococcus lactis for Microbe-Gut-Brain Axis Regulating via Upconversion Optogenetic Micro-Nano

Huizhuo Pan^1,2, Tao Sun^3,4, Meihui Cui^1,2

¹School of Life Sciences, Tianjin University, Tianjin, 300072, China.

|April 1, 2022

Summary

Engineered probiotics, controlled by light, can remotely regulate brain functions like anxiety and Parkinson's disease. This novel gut-brain axis therapy offers precise control over host health via engineered microbes.

Keywords:

gut-brain axis intestine targeting delivery microbial therapy optogenetics upconversion materials

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Area of Science:

Microbiology
Neuroscience
Biotechnology

Background:

The gut-brain axis highlights the gut microbiota's influence on brain function.
Engineered bacteria show promise as live biotherapeutic agents for homeostasis.
The potential for engineered microbes to remotely regulate brain function in vivo remains unexplored.

Purpose of the Study:

To engineer blue-light-responsive probiotics for targeted gut-brain axis modulation.
To investigate the in vivo efficacy of these probiotics in regulating brain functions.

Main Methods:

Development of blue-light-responsive engineered probiotics (Lactococcus lactis).
Utilization of an upconversion optogenetic micro-nano system for spatiotemporal control.
Administration of probiotics as oral live biotherapeutic agents.

Main Results:

Successful engineering of probiotics for precise control via optogenetics.
Demonstrated targeted delivery and production of engineered bacteria in the small intestine.
Achieved precise manipulation of brain functions, including anxiety behavior and Parkinson's disease models, and vagal afferent activity.

Conclusions:

Engineered probiotics, controlled by light, offer a noninvasive strategy for gut-brain axis regulation.
This approach enables controllable communication from the gut to the host brain.
Potential for accurate and effective health regulation using engineered microbes is established.