Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spectroscopic methods in degenerative neurological diseases.

D A Butterfield

    CRC Critical Reviews in Clinical Neurobiology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder.

    Free radical biology & medicine·2021
    Same author

    Linkages between mineralogy, fluid chemistry, and microbial communities within hydrothermal chimneys from the Endeavour Segment, Juan de Fuca Ridge.

    Geochemistry, geophysics, geosystems : G(3)·2018
    Same author

    Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways.

    Biochimica et biophysica acta·2016
    Same author

    Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment.

    Free radical biology & medicine·2014
    Same author

    Vitamin E is essential for Purkinje neuron integrity.

    Neuroscience·2013
    Same author

    Annexin A1 complex mediates oxytocin vesicle transport.

    Journal of neuroendocrinology·2013

    Spectroscopic methods offer unifying insights into the molecular basis of degenerative neurological diseases by examining cell membranes. These techniques, including electron spin resonance and nuclear magnetic resonance, illuminate disease pathogenesis.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Spectroscopy

    Background:

    • The molecular underpinnings of many neurodegenerative diseases are not fully understood.
    • While biochemical, morphological, and genetic studies offer clues, spectroscopic investigations provide unifying molecular insights.
    • Cell membranes are crucial in understanding these disorders, with erythrocytes serving as a key model.

    Purpose of the Study:

    • To review spectroscopic techniques applicable to degenerative neurological diseases.
    • To summarize current knowledge of cell membrane structure and function, focusing on erythrocytes.
    • To critically evaluate the literature on spectroscopic methods in the context of neurodegenerative disorders.

    Main Methods:

    • Electron Spin Resonance (ESR) spectroscopy

    Related Experiment Videos

  • Nuclear Magnetic Resonance (NMR) spectroscopy
  • Fluorescence spectroscopy
  • Raman spectroscopy

    • Main Results:

    • Spectroscopic studies of cell membranes have yielded significant insights into the pathogenesis of degenerative neurological diseases.
    • These methods can identify molecular defects contributing to disease etiology.
    • Focus on erythrocyte membranes provides a model for broader neurological applications.

    Conclusions:

    • Spectroscopic techniques are powerful tools for elucidating the molecular basis of neurodegenerative diseases.
    • Understanding cell membrane alterations is key to unraveling disease mechanisms.
    • Further critical evaluation of spectroscopic literature will advance research in this field.