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Updated: Sep 28, 2025
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
Pathogenicity and virulence of Marburg virus
Mehedy Hasan Abir1, Tanjilur Rahman2, Ayan Das2
1Faculty of Food Science and Technology, Chattogram Veterinary and Animal Sciences University, Chittagong, Bangladesh.
Abstract:
Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and human-to-human transmission had major roles in the amplification of MARV outbreaks in African countries. The high fatality rate of up to 90% demands the broad study of MARV diseases (MVD) that correspond with MARV infection. Since large outbreaks are rare for MARV, clinical investigations are often inadequate for providing the substantial data necessary to determine the treatment of MARV disease. Therefore, an overall review may contribute to minimizing the limitations associated with future medical research and improve the clinical management of MVD. In this review, we sought to analyze and amalgamate significant information regarding MARV disease epidemics, pathophysiology, and management approaches to provide a better understanding of this deadly virus and the associated infection.
Insights
Marburg virus (MARV) causes severe hemorrhagic fever with high fatality. This review synthesizes epidemic, pathophysiology, and management data to improve understanding and clinical care for Marburg virus disease (MVD).
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Marburg virus (MARV) causes severe hemorrhagic fever with high fatality rates, posing a significant public health concern since 1967.
- Outbreaks in 1998 and 2004 highlight the virus's potential for widespread transmission, often amplified by zoonotic spillover from fruit bats and subsequent human-to-human spread.
- The high mortality rate of Marburg virus disease (MVD) necessitates comprehensive research for effective treatment and management strategies.
Purpose of the Study:
- To analyze and amalgamate significant information regarding Marburg virus disease (MVD) epidemics.
- To elucidate the pathophysiology of MARV infection.
- To review current and potential management approaches for MVD.
Main Methods:
- Systematic literature review of Marburg virus (MARV) disease epidemics.
- Analysis of published data on MARV pathophysiology.
- Compilation of information on MVD management strategies.
Main Results:
- MARV outbreaks have historically been linked to specific geographic regions and transmission routes, including zoonotic and human-to-human pathways.
- Understanding MARV pathophysiology is crucial for developing targeted interventions.
- Current management of MVD relies on supportive care, with limited specific antiviral treatments available.
Conclusions:
- A comprehensive understanding of MARV epidemics, pathophysiology, and management is essential for improving clinical outcomes.
- This review aims to consolidate existing knowledge to address limitations in current research and clinical practice for MVD.
- Further research is needed to develop effective treatments and enhance the clinical management of Marburg virus disease.
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