Related Experiment Video
Updated: Sep 28, 2025
11:54
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
30.9K
CRS-PRO and SNOT-22 correlations with type 2 inflammatory mediators in chronic rhinosinusitis
Samuel D Racette1, Alexander L Schneider1, Meera Ganesh1
1Department of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.
International Forum of Allergy & Rhinology
|April 1, 2022
Summary
The Patient Reported Outcomes in Chronic Rhinosinusitis (CRS-PRO) instrument correlates better with type 2 biomarkers after surgery than the SNOT-22, especially in patients with nasal polyps. This suggests CRS-PRO may be more sensitive in assessing treatment outcomes.
Area of Science:
- Otolaryngology
- Immunology
- Patient-Reported Outcomes Research
Background:
- Chronic rhinosinusitis (CRS) is a common condition affecting quality of life.
- Validated patient-reported outcome measures (PROMs) like the SNOT-22 and CRS-PRO are crucial for assessing treatment efficacy.
- Type 2 (T2) biomarkers are implicated in the pathophysiology of CRS, particularly in cases with nasal polyps.
Purpose of the Study:
- To evaluate the correlation between SNOT-22 and CRS-PRO scores with T2 biomarkers (IL-4, IL-5, IL-13, ECP) before and after endoscopic sinus surgery (ESS).
- To compare the responsiveness of SNOT-22 and CRS-PRO to changes in T2 biomarkers following ESS in CRS patients.
Main Methods:
- 123 CRS patients (71 CRSsNP, 52 CRSwNP) completed SNOT-22 and CRS-PRO pre- and post-ESS (6-12 months).
- Middle meatal mucus was analyzed for T2 biomarkers (IL-4, IL-5, IL-13, ECP) using multiplexed bead assay and ELISA.
- Statistical analysis compared PROM scores with biomarker levels at different time points and disease phenotypes.
Main Results:
- Neither PROM correlated with biomarkers pre-ESS.
- Post-ESS, CRS-PRO correlated with IL-5 and IL-13, while SNOT-22 did not.
- In CRSwNP patients, post-ESS CRS-PRO correlated with IL-5, IL-13, and ECP; SNOT-22 correlated with IL-5 and IL-13.
- The SNOT-22 rhinologic and CRS-PRO rhinopsychologic subdomains showed better biomarker correlations.
Conclusions:
- The CRS-PRO demonstrates a significant correlation with T2 biomarkers, particularly post-ESS and in CRSwNP patients.
- CRS-PRO may offer a more sensitive assessment of treatment response compared to SNOT-22 in specific CRS phenotypes.
- Further research into subdomain analysis could refine the utility of PROMs in T2-high CRS.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
3.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
3.2K
01:16Drugs Used in Upper Respiratory Disorders: Overview
389
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
389
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
243
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
243
01:26Asthma-II: Pathophysiology and Classification
3.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.0K
01:17Drugs Used in Lower Respiratory Disorders: Overview
657
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
657