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Updated: Sep 28, 2025

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
Published on: September 15, 2016
Locally produced autoantibodies in cancer
Sara M Centuori1, Deepta Bhattacharya2
1Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA; Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA; University of Arizona Cancer Center, Tucson, AZ, USA.
Abstract:
The function and antigen-specificities of tumor-infiltrating B cells are mostly unknown. In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022).
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