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Early brain activity: Translations between bedside and laboratory
Heiko J Luhmann1, Patrick O Kanold2, Zoltán Molnár3
1Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, Mainz, Germany.
Progress in Neurobiology
|April 1, 2022
Summary
Assessing neural activity in preclinical models and humans is crucial for understanding neurodevelopmental disorders. This review highlights challenges and opportunities in translating research for better diagnostics and treatments.
Area of Science:
- Neuroscience
- Developmental Biology
- Clinical Research
Background:
- Neural activity critically influences brain development and reflects its processes.
- Alterations in neuronal activity are implicated as both causes and consequences of neurodevelopmental issues.
Purpose of the Study:
- To review methods for assessing neuronal activity in preclinical and clinical settings.
- To identify translational research priorities, challenges, and solutions in neurodevelopmental disorders.
Main Methods:
- Review of existing literature on preclinical and clinical assessment of neural activity.
- Analysis of translational bottlenecks in neurodevelopmental research.
Main Results:
- Significant differences exist in measurable neural activity between animal models and human subjects.
- Relating neural activity measurements to specific developmental stages remains a challenge.
- Balancing practical, ethical, and methodological considerations is essential for advancing the field.
Conclusions:
- Urgent translational research is needed to bridge the gap between preclinical findings and clinical applications.
- Overcoming measurement, developmental stage, and ethical challenges is key to improving neurodevelopmental diagnostics and therapeutics.
