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Detection of microplastics in human lung tissue using μFTIR spectroscopy
Lauren C Jenner1, Jeanette M Rotchell2, Robert T Bennett3
1Hull York Medical School, University of Hull, Hull HU6 7RX, United Kingdom.
The Science of the Total Environment
|April 1, 2022
Summary
Airborne microplastics (MPs) were detected in human lung tissue, confirming inhalation as a potential exposure route. This study identified various polymer types, providing crucial data for future health impact assessments.
Area of Science:
- Environmental Science
- Toxicology
- Pulmonology
Background:
- Airborne microplastics (MPs) are globally prevalent, with higher concentrations near human activity.
- Occupational exposure to MPs has been linked to respiratory issues.
- The presence and accumulation of environmental MPs within human lungs remain under investigation.
Purpose of the Study:
- To detect and characterize microplastics (MPs) in human lung tissue.
- To determine if environmental MPs can be inhaled, deposited, and accumulated in the lungs.
- To provide data for future laboratory exposure experiments assessing health impacts.
Main Methods:
- Analysis of digested human lung tissue samples (n=13) using μFTIR spectroscopy (≥3 μm detection limit).
- Rigorous contamination control measures were implemented.
- Quantification and polymer identification of detected MPs.
Main Results:
- 39 MPs were identified in 11 out of 13 lung tissue samples.
- Average MP levels in lung tissue were significantly higher than procedural blanks (p=0.001).
- Polypropylene, polyethylene terephthalate, and resin were the most abundant polymer types detected, with higher concentrations found in the lower lung regions.
Conclusions:
- The study provides the first evidence of microplastic presence in human lungs.
- Inhalation is a viable route for environmental MP exposure.
- Characterization of MP types and levels in lungs informs future toxicological studies on health effects.
