Related Experiment Video
Updated: Sep 28, 2025
Author Spotlight: Exploring the Link Between Time Perception of Visual Stimuli and Reading Skills
Published on: January 19, 2024
Bromazepam increases the error of the time interval judgments and modulates the EEG alpha asymmetry during time
Paulo Ramiler Silva1, Victor Marinho2, Francisco Magalhães2
1Neuro-Innovation Technology & Brain Mapping Laboratory, Federal University of Delta of Parnaíba, Parnaíba, Brazil; Master Program in Biotechnology, Federal University of Delta of Parnaíba, Parnaíba, Brazil.
Aim:
This study investigated the bromazepam effects in male subjects during the time estimation performance and EEG alpha asymmetry in electrodes associated with the frontal and motor cortex.
Material And Methods:
This is a double-blind, crossover study with a sample of 32 healthy adults under control (placebo) vs. experimental (bromazepam) during visual time-estimation task in combination with electroencephalographic analysis.
Results:
The results demonstrated that the bromazepam increased the relative error in the 4 s, 7 s, and 9 s intervals (p = 0.001). In addition, oral bromazepam modulated the EEG alpha asymmetry in cortical areas during the time judgment (p ≤ 0.025).
Conclusion:
The bromazepam decreases the precision of time estimation judgments and modulates the EEG alpha asymmetry, with greater left hemispheric dominance during time perception. Our findings suggest that bromazepam influences internal clock synchronization via the modulation of GABAergic receptors, strongly relating to attention, conscious perception, and behavioral performance.
Related Concept Videos
01:29Anxiolytic Drugs: Benzodiazepines and Buspirone
01:14CNS Depressants: Barbiturates and Benzodiazepines
01:19Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...