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Updated: Sep 28, 2025
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Molecularly imprinted sensing platform based on electrochemically modified graphite paper for efficient detection of
Hai Chi1, Yujie Li1, Guoqin Liu2
1School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Abstract:
In this study, a molecularly imprinted polymer (MIP) electrochemical sensor based on electrochemically modified graphite paper (EM-GP) was developed for the detection of 3-MCPD for the first time. To this end, Prussian blue (PB) was electrodeposited on EM-GP to yield uniformly distributed PtNPs. The successful preparation of Pt@PB/EM-GP was verified by SEM, Raman spectroscopy, XRD,XPS, and EDS. MIP was then prepared by CV electropolymerization with template molecules (3-MCPD), and density functional theory (DFT) at M06-2X/6-31 + g (d,p) level was used to calculate the molecular-level interaction between 3-MCPD and MIP. Under the optimum conditions, the dynamic linear range of the sensing platform varied from 1 × 10-8mol/L to 5 × 10-5mol/L with a detection limit estimated to 5 × 10-9 mol/L (S/N = 3). Overall, these findings look promising for the construction of selective and quick detection platforms of 3-MCPD in food samples.
