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The relationship between peripheral blood inflammatory markers and diabetic macular edema in patients with severe
1Department of Ophthalmology, The First People's Hospital of Nantong, Nantong, China.
Background:
Diabetic macular edema (DME) is a serious complication of diabetic retinopathy (DR). Recent studies have shown that inflammation is closely associated with the development of DME, and peripheral blood inflammatory markers [white blood cell (WBC) count and its subtypes] are relatively simple and easy to detect. Here, we investigated the relationship between peripheral blood inflammatory markers and macular edema in patients with severe DR (including both severe non-proliferative DR and proliferative DR).
Methods:
A total of 42 patients with severe DR were included in this study and divided into two groups: a severe DR with DME group (DME group, n=18) and a severe DR without DME group (non-DME group, n=24). Ophthalmologic findings and hematologic results were retrospectively retrieved from hospitalization records and databases.
Results:
The neutrophil percentage was significantly higher in the DME group (62.52%±8.21%) than in the non-DME group (57.30%±8.17%) (P<0.05); in contrast, the lymphocyte percentage was significantly lower in the DME group (28.09%±7.45%) than in the non-DME group (33.54%±7.29%) (P<0.05). Logistic regression analysis showed a significant correlation between lymphocyte percentage and DME [odds ratio (OR) =0.654, 95% CI: 0.436-0.851; P=0.011].
Conclusions:
Lymphocyte percentage can be used as an inflammatory marker for the development of DME in patients with severe DR.
Insights
Lower lymphocyte percentage in peripheral blood may indicate diabetic macular edema (DME) in patients with severe diabetic retinopathy (DR). This finding highlights lymphocyte percentage as a potential inflammatory marker for DME development.
Area of Science:
- Ophthalmology
- Hematology
- Diabetology
Background:
- Diabetic macular edema (DME) is a severe complication of diabetic retinopathy (DR).
- Inflammation plays a key role in the development of DME.
- Peripheral blood inflammatory markers offer a simple detection method.
Purpose of the Study:
- To investigate the association between peripheral blood inflammatory markers and macular edema in patients with severe DR.
- To determine if specific white blood cell (WBC) subtypes correlate with DME presence.
Main Methods:
- Retrospective analysis of 42 patients with severe DR.
- Patients categorized into severe DR with DME (n=18) and severe DR without DME (n=24) groups.
- Ophthalmologic and hematologic data were collected from medical records.
Main Results:
- Neutrophil percentage was significantly higher in the DME group compared to the non-DME group (P<0.05).
- Lymphocyte percentage was significantly lower in the DME group compared to the non-DME group (P<0.05).
- Logistic regression revealed a significant correlation between lower lymphocyte percentage and DME (OR=0.654, P=0.011).
Conclusions:
- Lymphocyte percentage serves as a valuable inflammatory marker for predicting DME development in severe DR patients.
- Peripheral blood lymphocyte levels can aid in assessing DME risk in diabetic retinopathy.
