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Updated: Sep 28, 2025

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
Soft Tissue and Osseous Substitutes for the Diabetic Foot
Steven L Stuto1, Crystal L Ramanujam1, Thomas Zgonis1
1Division of Podiatric Medicine and Surgery, Department of Orthopaedics, University of Texas Health San Antonio, 7703 Floyd Curl Drive, MC 7776, San Antonio, TX 78229, USA.
Abstract:
Several soft tissue and osseous substitutes have become widely available for consideration in diabetic foot and ankle reconstruction. Although autogenous skin and bone grafts remain the gold standard, the diabetic foot often presents with challenging clinical scenarios in which these options are limited or contraindicated. Selection of the appropriate substitute depends on the patient's medical status, type and extent of soft tissue and bone loss, and expected function of the given site. This article reviews several of the specific advanced orthobiologics and their clinical indications.
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