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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Soft Tissue and Osseous Substitutes for the Diabetic Foot.

Steven L Stuto1, Crystal L Ramanujam1, Thomas Zgonis1

  • 1Division of Podiatric Medicine and Surgery, Department of Orthopaedics, University of Texas Health San Antonio, 7703 Floyd Curl Drive, MC 7776, San Antonio, TX 78229, USA.

Clinics in Podiatric Medicine and Surgery
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PubMed
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Advanced orthobiologics offer solutions for diabetic foot and ankle reconstruction when traditional grafts are not feasible. This review discusses various substitutes and their specific clinical uses in complex cases.

Keywords:
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Area of Science:

  • Orthopedics
  • Biomaterials Science
  • Diabetic Foot Care

Background:

  • Diabetic foot and ankle reconstruction presents unique challenges.
  • Autogenous grafts are standard but often limited in diabetic patients.
  • Availability of soft tissue and osseous substitutes has increased.

Purpose of the Study:

  • To review advanced orthobiologics for diabetic foot and ankle reconstruction.
  • To discuss clinical indications for various substitutes.
  • To guide selection based on patient status and defect type.

Main Methods:

  • Literature review of advanced orthobiologics.
  • Analysis of clinical indications and patient factors.
  • Synthesis of current evidence on substitute use.

Main Results:

  • Several orthobiologic substitutes are available for diabetic foot reconstruction.
  • Selection criteria include patient health, tissue loss, and functional demands.
  • Specific advanced materials have defined roles in complex cases.

Conclusions:

  • Orthobiologics provide viable alternatives in diabetic foot reconstruction.
  • Careful patient and defect assessment is crucial for appropriate substitute selection.
  • These advanced materials expand treatment options for challenging scenarios.