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Ribociclib-induced extensive vitiligo-like lesions: possible pathomechanisms with clinical, dermoscopic and
Gopikrishnan Anjaneyan1, Pavithran Keechilat2, Prasanna Duraisamy3
1Department of Dermatology, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India drgopikrishnana@gmail.com.
Abstract:
Cyclin dependent kinase (CDK) 4/6 inhibitors are targeted agents which act on cyclin-D and these combined with hormonal therapy have been approved for the treatment of locally advanced or metastatic breast cancer. CDK 4/6 inhibitors have been found to have a tolerable adverse event profile; however, they have been associated with various dermatological adverse events. We report a case of ribociclib-induced vitiligo and discuss the clinical, dermoscopic and histological features with a review of the various possible pathomechanisms involved.
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