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Area of Science:

  • Computational Biology
  • Bioinformatics
  • Genomics

Background:

  • Protein structure prediction is a long-standing challenge in computational biology.
  • Deep Learning (DL) has emerged as a powerful tool for biological data analysis.

Purpose of the Study:

  • To review recent advances in DL applications across five key areas of biosciences.
  • To identify limitations and future perspectives of DL in these areas.

Main Methods:

  • Review of recent literature on DL in computational biology.
  • Analysis of DL applications in protein structure/function prediction, genome engineering, systems biology, and phylogenetic inference.

Main Results:

  • DL has achieved significant breakthroughs, particularly in protein structure prediction.
  • Key bottlenecks include training data, problem scope, and adaptability of DL architectures.

Conclusions:

  • DL holds immense potential for biosciences but faces challenges.
  • Addressing data limitations and architectural adaptability is crucial for future progress.