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Mapping Research on miRNAs in Cancer: A Global Data Analysis and Bibliometric Profiling Analysis
Peter Shaw1,2, Kartik Lokhotiya3, Chellan Kumarasamy4
1Oujiang Laboratory, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China.
Summary
This study analyzed global research on microRNAs (miRNAs) in cancer diagnosis and prognosis. China leads in publications, while the US leads in citations, highlighting significant research output and trends in this vital oncology field.
Area of Science:
- Oncology
- Biomarkers
- Genomics
Background:
- MicroRNAs (miRNAs) are crucial in oncology due to their roles in malignancy.
- While numerous miRNA studies exist, a comprehensive analysis of their clinical implications in cancer diagnosis and prognosis is lacking.
- This gap highlights the need for a bibliometric evaluation of the research landscape.
Purpose of the Study:
- To conduct a large-scale, global bibliometric analysis of research on the clinical implications of miRNAs in cancer diagnosis and prognosis.
- To map the research output, identify key topics, seminal papers, and research directions.
- To provide a performance assessment of research productivity and quality in this field.
Main Methods:
- Systematic search of the SCOPUS database for relevant studies from 2003 to 2019.
- Bibliometric analysis using SPSS software to calculate indicators like publication year, country, author, journal, and institution.
- Analysis of annual research output, citations, and H-index to assess productivity and impact.
Main Results:
- A total of 18,636 articles on miRNA-cancer research were retrieved.
- Publication growth accelerated significantly between 2012-2019 (90.71%) compared to 2003-2011 (9.29%).
- China led in publications (41%), while the US led in citations (48%). 'Oncotarget' published most articles, and 'Cancer Research' received most citations.
Conclusions:
- Bibliometric parameters reveal crucial insights into research productivity and quality in miRNA-cancer studies.
- The findings offer a valuable reference for oncologists, scientists, and policymakers.
- This analysis delineates the current research landscape and informs future directions in miRNA-based cancer diagnostics and prognostics.
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