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Recent Developments in Multi-component Synthesis of Lawsone Derivatives
Komal Chandrakar1, Jeevan Lal Patel1, Rajeswar Rao Vedula2
1Department of Chemistry, National Institute of Technology Raipur, G.E. Road, Raipur-492010, Chhattisgarh, India.
Background:
2-Hydroxy-1,4-Naphthoquinone (HNQ; Lawsone) is one of the most useful and the simplest naturally occurring naphthoquinones and has stimulated a resurgence of interest in the past decades due to a wide range of pharmacological activities.
Introduction And Methods:
This activity has led to the unusually large emphasis being placed on the design of more efficient multi-component reactions (MCRs) in the synthesis of bioactive lawsone derivatives.
Results And Conclusion:
This review highlights the recent developments in multi-component synthesis of biologically relevant naphthoquinone linked and fused heterocyclic derivatives carried out from 2015 till now.
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