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Supportive Oncodermatology in Pediatric Patients

Danny W Linggonegoro1, Hannah Song1, Jennifer T Huang1

  • 1Boston Children's Hospital, Dermatology Program, 300 Longwood Avenue, Fegan 6, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.

Dermatologic Clinics
|April 3, 2022
PubMed

Insights

Pediatric targeted therapy use is increasing, leading to diverse skin reactions. Research is growing on these reactions, especially for BRAF, MEK, and EGFR inhibitors, with more data on timing and treatment.

Area of Science:

  • Pediatric dermatology
  • Oncology
  • Pharmacology

Background:

  • Targeted therapies are increasingly used in pediatric oncology.
  • These therapies can cause a variety of cutaneous reactions.
  • Literature on pediatric-specific reactions is still developing.

Purpose of the Study:

  • To review the emerging literature on pediatric cutaneous reactions to targeted therapies.
  • To highlight the types, prevalence, and management of these reactions.
  • To identify areas with the most available data.

Main Methods:

  • Literature review of pediatric dermatology and oncology studies.
  • Focus on targeted therapies including receptor, signaling, antiangiogenesis, and immunotherapy agents.
  • Analysis of data on reaction timing, severity, and treatment.

Main Results:

  • Cutaneous reactions to targeted therapies are common and diverse in children.
  • Emerging data covers various targeted agents, with most information available for BRAF, MEK, and EGFR inhibitors.
  • Specific details on timing, severity, and treatment algorithms are most abundant for these inhibitors.

Conclusions:

  • Pediatricians and dermatologists must be aware of potential skin toxicities from targeted cancer drugs.
  • Further research is needed to fully characterize and manage all types of drug-induced skin reactions in children.
  • Standardized data collection on reaction characteristics is crucial for developing optimal treatment guidelines.
Keywords:
Cutaneous reactionManagementOncodermatologyPediatric dermatologyTargeted therapy

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