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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies
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Stem cells in neonatal diseases: An overview.

Sushma Chaubey1, Vineet Bhandari2

  • 1Department of Biomedical Engineering, Widener University, Chester, PA, 19013, USA.

Seminars in Fetal & Neonatal Medicine
|April 3, 2022
PubMed
Summary

Stem cell therapy shows promise for treating preterm birth complications. Research reviews pre-clinical and clinical studies on stem cells and their secretome for neonatal diseases, offering new therapeutic insights.

Keywords:
Extracellular vesiclesNeonatal disordersParacrinePreterm birthRegenerative medicineSecretomeStem cell therapyStem cells

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Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
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Area of Science:

  • Neonatal Medicine
  • Regenerative Medicine
  • Perinatal Research

Background:

  • Preterm birth complications are leading causes of infant mortality and morbidity.
  • Current neonatal intensive care has limitations, with a lack of effective preventive or therapeutic strategies.
  • Stem cell (SC) therapy is a promising novel approach for neonatal diseases.

Purpose of the Study:

  • To review pre-clinical and clinical studies on stem cell therapy for preterm and term birth-related diseases.
  • To explore the role of stem cell secretome, conditioned media, and extracellular vesicles in neonatal conditions.
  • To provide insights into future therapeutic applications of stem cells in neonatal medicine.

Main Methods:

  • Comprehensive literature review of pre-clinical and clinical studies.
  • Analysis of stem cell types and their therapeutic mechanisms in neonatal diseases.
  • Evaluation of stem cell secretome and extracellular vesicle contributions.

Main Results:

  • Stem cell therapy demonstrates encouraging pre-clinical results for various neonatal diseases.
  • The therapeutic efficacy of stem cells is linked to their secretome and paracrine actions.
  • Evidence suggests potential for stem cell-based treatments in neonatal medicine.

Conclusions:

  • Stem cell therapy, including its secretome, holds significant potential for treating neonatal diseases.
  • Further research and clinical translation are needed to fully realize the benefits of stem cell therapy for newborns.
  • This review highlights stem cells as a promising future therapeutic avenue in neonatal care.