Related Experiment Video

Updated: Sep 28, 2025

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)
06:41

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)

Published on: January 10, 2025

709

Recent trends of natural based therapeutics for mitochondria targeting in Alzheimer's disease

Ashish Dhiman1, Mayank Handa1, Munindra Ruwali2

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow, UP 226002, India.

Mitochondrion
|April 3, 2022
PubMed

Insights

Alzheimer's disease involves mitochondrial dysfunction, impacting energy and cell regulation. Natural products may offer therapeutic potential by targeting these pathways.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by cognitive decline.
  • The precise pathophysiology of AD remains incompletely understood.
  • Mitochondrial dysfunction, including oxidative stress and altered calcium homeostasis, is increasingly implicated in AD pathogenesis.

Purpose of the Study:

  • To review the role of mitochondrial dysfunction in Alzheimer's disease.
  • To explore mitochondrial dynamics, including fusion and fission, in AD.
  • To examine the interplay between aging, cell cycle regulation, and energy metabolism in AD.

Main Methods:

  • Literature review focusing on mitochondrial mechanisms in AD.
  • Analysis of research on aging and its connection to cellular processes.
  • Synthesis of information on natural product-based therapeutic strategies.

Main Results:

  • Mitochondrial dysfunction is a key feature in Alzheimer's disease pathophysiology.
  • Mitochondrial dynamics (fusion/fission) are altered in AD.
  • Aging exacerbates mitochondrial dysfunction and impacts cell cycle regulation and energy status.

Conclusions:

  • Targeting mitochondrial dysfunction is a promising therapeutic avenue for AD.
  • Natural products offer potential for multi-pathway intervention against AD-related mitochondrial damage.
  • Understanding the link between aging, mitochondria, and cell cycle is crucial for AD prevention and treatment.
Keywords:
Alzheimer’s diseaseApoptosisClinicalMitochondriaPhytochemicalsReactive oxygen species (ROS)

More Related Videos

Author Spotlight: Decoding Mitochondrial Aging08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

4.2K
Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.6K

Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
274
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
15.2K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
705
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.3K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.6K
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
12.6K