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Related Concept Videos

Preventive Healthcare Services01:30

Preventive Healthcare Services

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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Related Experiment Video

Updated: Sep 28, 2025

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Multicancer Early detection Panels (MCEDs) in the Primary Care Setting.

Benjamin E Ueberroth1, Lisa A Marks2, Mitesh J Borad3

  • 1Department of Internal Medicine, Mayo Clinic, 13737 North 92nd Street, Scottsdale, Phoenix, AZ 85260, United States.

The American Journal of Medicine
|April 3, 2022
PubMed
Summary

New multicancer early detection tests are available, but their impact on primary care is unclear. This review offers a framework for primary care providers (PCPs) to manage these tests, addressing patient counseling, costs, and anxiety.

Keywords:
Blood-basedEarly detectionMCEDMulticancerPan-cancer

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Area of Science:

  • Oncology
  • Primary Care Medicine
  • Molecular Diagnostics

Background:

  • Multicancer early detection (MCED) blood tests are now accessible to patients via prescription.
  • The practical implications of MCED tests in primary care settings remain largely unexamined.
  • Potential challenges include patient counseling, cost, testing frequency, and managing positive results.

Purpose of the Study:

  • To review the existing literature on MCED tests in primary care.
  • To provide a practical framework for primary care providers (PCPs) regarding MCED test use.
  • To guide PCPs in discussing MCED tests with patients and integrating them into practice.

Main Methods:

  • Systematic literature review of studies on MCED tests in primary care.
  • Analysis of current evidence regarding clinical utility and implementation challenges.
  • Development of a decision-making and management framework for PCPs.

Main Results:

  • Limited real-world data exists on the impact of MCED tests in primary care.
  • Key concerns identified include patient anxiety, cost-effectiveness, and the diagnostic yield of positive results.
  • PCPs require guidance on test interpretation and follow-up protocols.

Conclusions:

  • MCED tests present both opportunities and challenges for primary care.
  • A structured approach is needed to optimize the use of MCED tests, ensuring patient benefit and efficient healthcare delivery.
  • Further research is essential to evaluate the long-term impact and cost-effectiveness of MCED screening.