Related Experiment Video

Updated: Sep 28, 2025

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

19.4K

A Study of Urodynamic Parameters at Different Bladder Filling Stages for Predicting Upper Urinary Tract Dilatation

Lei Lyu1, Ya Xiong Yao2, Er Peng Liu1

  • 1Henan Joint International Paediatric Urodynamic Laboratory, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

International Neurourology Journal
|April 4, 2022
PubMed

Insights

Low bladder compliance and high detrusor pressure during bladder filling are better predictors of upper urinary tract dilatation in children with neurogenic bladder. A detrusor leak point pressure over 20 cm H2O is also a sensitive indicator.

Area of Science:

  • Pediatric Urology
  • Nephrology
  • Urodynamics

Background:

  • Neurogenic bladder (NB) in children can lead to upper urinary tract dilatation (UUTD).
  • Accurate prediction of UUTD is crucial for timely intervention.
  • Current predictors may lack sufficient accuracy in NB patients.

Purpose of the Study:

  • To identify more accurate predictors of UUTD in children with NB.
  • To investigate the relationship between urodynamic parameters, detrusor leak point pressure (DLPP), and UUTD.
  • To compare the predictive value of different urodynamic parameters at various bladder filling stages.

Main Methods:

  • 158 children (3-16 years) with NB were analyzed.
  • Patients were divided into UUTD (39) and control (119) groups.
  • Bladder compliance (BC) and detrusor pressure (△Pdet) were measured at early, middle, and end filling stages; DLPP was recorded at end filling.

Main Results:

  • Low BC (<8 mL/cm H2O) in middle/end stages showed higher specificity for UUTD.
  • High △Pdet (>8, >20, >25 cm H2O in early, middle, end stages respectively) demonstrated higher sensitivity for UUTD prediction.
  • A DLPP cutoff of 20 cm H2O was more sensitive in predicting UUTD than 40 cm H2O.

Conclusions:

  • Reduced bladder compliance and elevated detrusor pressure during middle and end filling stages are superior predictors of UUTD in NB.
  • A DLPP >20 cm H2O at end bladder filling stage indicates high sensitivity for UUTD prediction.
  • These urodynamic findings offer improved accuracy over classic indicators for UUTD risk stratification in pediatric NB.
Abstract

Keywords:
ChildDetrusor leak point pressureDetrusor pressureUpper urinary tract dilatationladder compliance

More Related Videos

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models10:19

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

19.4K
Author Spotlight: Enhanced Urodynamic Method for Precise Urine Measurement in Awake Mice with Neurogenic Bladder06:46

Author Spotlight: Enhanced Urodynamic Method for Precise Urine Measurement in Awake Mice with Neurogenic Bladder

Published on: June 7, 2024

908

Related Concept Videos

Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
836
Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

Imaging Studies VI: Voiding Cystourethrography and Cystography

Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
194
Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
1.7K
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
246
Imaging Studies II: Ultrasonography01:24

Imaging Studies II: Ultrasonography

IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
71
Imaging Studies V: Intravenous Urography and Retrograde Pyelography01:22

Imaging Studies V: Intravenous Urography and Retrograde Pyelography

IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
235