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Endocrinal dysfunction in children with Down syndrome.

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This article reviews endocrine disorders in children with Down syndrome (DS), offering pediatricians guidance on diagnosis and management. It highlights the increased risk of hormonal conditions in infants with DS.

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Area of Science:

  • Pediatric Endocrinology
  • Genetics
  • Internal Medicine

Background:

  • Down syndrome (DS) is the most common genetic disorder.
  • Children with DS face a higher risk of endocrine comorbidities.
  • Understanding these risks is crucial for pediatric care.

Purpose of the Study:

  • To provide pediatricians with a narrative overview of endocrine disorders in children with DS.
  • To detail presentations, diagnoses, and management recommendations.
  • To synthesize current knowledge for clinical practice.

Main Methods:

  • Systematic literature search conducted across major databases (PubMed, Embase, Google Scholar, MEDLINE, EBSCO, Science Direct).
  • Identification and retrieval of relevant articles from electronic and print journals.
  • Focus on narrative review of endocrinal disorders in pediatric DS population.

Main Results:

  • Children with DS exhibit increased susceptibility to various endocrine conditions.
  • Specific endocrine disorders present unique diagnostic challenges.
  • Evidence-based management strategies are essential for affected children.

Conclusions:

  • Pediatricians require comprehensive knowledge of endocrine issues in DS.
  • Early diagnosis and tailored management improve outcomes for children with DS.
  • This review serves as a valuable resource for clinicians managing pediatric patients with Down syndrome.