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Endocrinal dysfunction in children with Down syndrome

Kotb Abbass Metwalley1, Hekma Saad Farghaly1

  • 1Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.

Annals of Pediatric Endocrinology & Metabolism
|April 4, 2022
PubMed

Insights

This article reviews endocrine disorders in children with Down syndrome (DS), offering pediatricians guidance on diagnosis and management. It highlights the increased risk of hormonal conditions in infants with DS.

Area of Science:

  • Pediatric Endocrinology
  • Genetics
  • Internal Medicine

Background:

  • Down syndrome (DS) is the most common genetic disorder.
  • Children with DS face a higher risk of endocrine comorbidities.
  • Understanding these risks is crucial for pediatric care.

Purpose of the Study:

  • To provide pediatricians with a narrative overview of endocrine disorders in children with DS.
  • To detail presentations, diagnoses, and management recommendations.
  • To synthesize current knowledge for clinical practice.

Main Methods:

  • Systematic literature search conducted across major databases (PubMed, Embase, Google Scholar, MEDLINE, EBSCO, Science Direct).
  • Identification and retrieval of relevant articles from electronic and print journals.
  • Focus on narrative review of endocrinal disorders in pediatric DS population.

Main Results:

  • Children with DS exhibit increased susceptibility to various endocrine conditions.
  • Specific endocrine disorders present unique diagnostic challenges.
  • Evidence-based management strategies are essential for affected children.

Conclusions:

  • Pediatricians require comprehensive knowledge of endocrine issues in DS.
  • Early diagnosis and tailored management improve outcomes for children with DS.
  • This review serves as a valuable resource for clinicians managing pediatric patients with Down syndrome.

Keywords:
Down syndromeHypothyroidismObesityShort stature

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