Cardiometabolic-based chronic disease: adiposity and dysglycemia drivers of heart failure

Area of Science:

• Cardiology
• Metabolic Diseases
• Chronic Disease Management

Background:

• Heart failure (HF) presents a significant global health challenge with high mortality and morbidity.
• Obesity and type 2 diabetes are key contributors to cardiometabolic-based chronic disease (CMBCD).
• The adiposity-based chronic disease (ABCD) and dysglycemia-based chronic disease (DBCD) models offer frameworks for understanding these drivers.

Purpose of the Study:

• To review the influence of ABCD and DBCD on the development and progression of HF phenotypes.
• To examine the links between ABCD and DBCD stages and cardiac structure, function, HF risk, and outcomes.
• To discuss interventions aimed at mitigating cardiac remodeling and improving outcomes in HF.

Main Methods:

• Literature review focusing on the CMBCD model.
• Analysis of relationships between ABCD/DBCD stages and HF.
• Synthesis of evidence on lifestyle, pharmacological, and procedural interventions.

Main Results:

• ABCD and DBCD significantly impact HF genesis and progression.
• Specific stages of these chronic diseases correlate with cardiac structural and functional changes, HF risk, and outcomes.
• Various interventions show potential for reversing cardiac remodeling and improving HF outcomes.

Conclusions:

• Driver-based chronic disease models highlight critical prevention targets for HF.
• Personalized care plans tailored to the CMBCD model are needed for effective HF management.
• Future research should focus on randomized trials investigating tailored therapies for the CMBCD model to reduce HF susceptibility and enhance outcomes.