Related Experiment Video
Updated: Sep 28, 2025

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
Molecular mechanisms linking stress and insulin resistance
Habib Yaribeygi1, Mina Maleki2, Alexandra E Butler3
1Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Abstract:
To date, there is ample evidence to support the strong relationship between stress and insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an upstream event for insulin resistance as well. It is widely recognized that diabetes mellitus is more prevalent among people who have a stressful lifestyle; however, the underlying mechanisms are not well understood. In the current study, we surveyed the scientific literature for possible interactions between stress and insulin resistance and found that stress can impair glucose homeostasis, working through at least six molecular pathways.
Related Concept Videos
Psychoneuroimmunology: Diabetes and Cancer
Insulin: The Receptor and Signaling Pathways
Hypothalamic-Pituitary Axis
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...

