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Updated: Sep 28, 2025
Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein
Published on: January 28, 2013
Association Between Circulating Retinol-Binding Protein 4 and Adverse Cardiovascular Events in Stable Coronary Artery
Insights
Higher retinol-binding protein 4 (RBP4) levels predict a greater risk of major adverse cardiovascular events (MACEs) in stable coronary artery disease (CAD) patients. This finding highlights RBP4 as a potential biomarker for cardiovascular risk stratification in this population.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Clinical Research
Background:
- Retinol-binding protein 4 (RBP4) is a potential biomarker for cardiovascular disease.
- Its predictive role in stable coronary artery disease (CAD) prognosis requires further clarification.
Purpose of the Study:
- To investigate the association between circulating RBP4 levels and major adverse cardiovascular events (MACEs).
- To assess RBP4 as a prognostic marker in Chinese patients with stable CAD.
Main Methods:
- A cohort study including 840 stable CAD patients with serum RBP4 measurements.
- Follow-up for a median of 2.3 years to record incident MACEs (e.g., acute coronary syndrome, stroke, cardiovascular death).
- Cox proportional hazards regression analysis was used to determine associations.
Main Results:
- Higher quartiles of serum RBP4 were significantly associated with increased MACE risk (HRs ranging from 2.27 to 2.38).
- Each 5 μg/ml increase in RBP4 concentration correlated with a 13% higher risk of MACEs (adjusted HR: 1.13).
- No significant modifying effects of baseline characteristics were observed.
Conclusions:
- Elevated circulating RBP4 levels are significantly linked to a higher risk of MACEs in patients with stable CAD.
- RBP4 may serve as a valuable prognostic biomarker for adverse cardiovascular outcomes in this patient group.
Background:
The predictive role of retinol-binding protein 4 (RBP4) in the adverse prognosis of patients with stable coronary artery disease (CAD) has not been well-defined. We thus conducted this cohort study to investigate the association between circulating RBP4 level and major adverse cardiovascular events (MACEs) in Chinese patients with stable CAD.
Methods:
Patients with stable CAD and serum RBP4 concentration measurement at admission between July 2012 and January 2015 were included. The primary outcome in this study was incident MACEs, which included acute coronary syndrome, heart failure, stroke, peripheral vascular disease, and cardiovascular death. Cox proportional hazards regression was adopted to investigate the association between RBP4 and the incidence of MACEs.
Results:
A total of 840 patients with stable CAD were analyzed. The mean age of patients was 61.2 ± 15.9 years, and 56.1% of them were men. After a median follow-up of 2.3 years, 129 MACEs were observed. Compared to participants exposed to the first quartile of serum RBP4 level, those in the second, the third, and the fourth quartiles had associated hazard ratios (HRs) of 2.38 [95% confidence interval (CI): 1.33-4.26], 2.35 (95% CI: 1.31-4.21), and 2.27 (95% CI: 1.28-4.04) after adjusted for confounders, respectively. Every 5 μg/ml increment in serum RBP4 concentration was associated with an adjusted HR of 1.13 (95% CI: 1.05-1.22) for the occurrence of MACEs. Subgroup analyses suggested no significant modifying effects of baseline characteristics for the association between RBP4 and MACEs in patients with stable CAD.
Conclusion:
Our finding suggested that the higher circulating RBP4 level was significantly associated with an increased risk of MACEs in patients with stable CAD.
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