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Association of Blood Pressure Genetic Risk Score with Cardiovascular Disease and CKD Progression: Findings from the

Jovia L Nierenberg1, Amanda H Anderson1, Jiang He1,2

  • 1Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.

Kidney360
|April 4, 2022
PubMed

Insights

Genetic risk for high blood pressure (BP) increases cardiovascular disease risk in patients with chronic kidney disease (CKD). However, this genetic predisposition does not appear to accelerate kidney disease progression.

Area of Science:

  • Genetics
  • Nephrology
  • Cardiology

Background:

  • Genetic predisposition to high blood pressure (BP) is linked to cardiovascular disease (CVD) in the general population.
  • The association between genetic BP risk and CVD or kidney disease progression in individuals with chronic kidney disease (CKD) remains understudied.
  • This study investigates the predictive value of genetic BP risk for CVD and CKD progression in a CKD cohort.

Purpose of the Study:

  • To determine if genetic risk scores for elevated blood pressure predict cardiovascular disease events in patients with CKD.
  • To assess whether genetic risk for high BP is associated with the progression of chronic kidney disease.
  • To examine these associations across different ancestral groups within the CKD population.

Main Methods:

  • Analysis of 1493 African-ancestry and 1581 European-ancestry participants from the Chronic Renal Insufficiency Cohort over 12 years.
  • Utilized Cox proportional hazards models to assess associations between BP genetic risk scores and outcomes.
  • Outcomes included incident cardiovascular disease (myocardial infarction, congestive heart failure, stroke) and CKD progression (end-stage kidney disease, eGFR halving).

Main Results:

  • In European-ancestry participants, increased systolic and pulse pressure genetic risk scores were associated with significantly higher CVD risk.
  • In African-ancestry participants, increased systolic and diastolic BP genetic risk scores were linked to a higher risk of CVD.
  • No significant association was found between genetic BP risk and the progression of chronic kidney disease in either ancestral group.

Conclusions:

  • Genetic predisposition to elevated blood pressure is a significant risk factor for cardiovascular disease in individuals with CKD.
  • Genetic risk for high BP does not appear to influence the rate of CKD progression.
  • These findings highlight the importance of considering genetic BP risk in managing cardiovascular health in CKD patients.
Abstract

Keywords:
CRIC Studyblood pressurecardiovascular diseasechronic kidney diseasedisease progressiongenetic risk scoregenetics

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