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Curative Therapies for Hepatitis C Virus Infection in Patients with Kidney Disease

Ian A Strohbehn1, Rituvanthikaa Seethapathy, Meghan Lee

  • 1Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Kidney360
|April 4, 2022
PubMed

Insights

Direct-acting antiviral therapies have made hepatitis C virus (HCV) curable. These effective treatments show high cure rates and good safety profiles in patients with kidney disease, including those with chronic kidney disease (CKD) and end-stage kidney disease (ESKD).

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) infection is prevalent in patients with kidney disease.
  • HCV is a risk factor for chronic kidney disease (CKD) progression and increases mortality in dialysis patients.
  • Kidney transplant recipients with HCV experience poorer outcomes.

Purpose of the Study:

  • To review the impact of direct-acting antiviral (DAA) therapies on patients with kidney disease.
  • To highlight the efficacy and safety of curative HCV treatments in CKD, end-stage kidney disease (ESKD), and transplant populations.

Main Methods:

  • Review of clinical trial and real-world data on DAA therapies in kidney disease patients.
  • Analysis of treatment outcomes, cure rates, and adverse events.

Main Results:

  • DAA therapies demonstrate extremely high cure rates for HCV in patients with kidney disease.
  • These treatments exhibit favorable safety and adverse event profiles in this vulnerable population.
  • Curative HCV therapy positively impacts outcomes for CKD, ESKD, and kidney transplant recipients.

Conclusions:

  • Direct-acting antiviral therapies have transformed HCV from a chronic illness to a curable condition for patients with kidney disease.
  • Curative HCV treatment offers significant benefits, improving morbidity, mortality, and transplant outcomes in affected individuals.

Keywords:
clinical nephrologyhepacivirushepatitis C viruskidney diseases

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