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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Correlation Between Crohn's Disease Activity and Serum Selenium Concentration.

Wu Yan1, Wei Meihao1, Song Zihan2

  • 1Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

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|April 4, 2022
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Summary

Serum selenium levels are inversely associated with Crohn's disease (CD) severity. Measuring selenium may help assess CD activity and monitor disease progression in patients.

Keywords:
Crohn's diseasedisease activitynutritionserum selenium level

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Area of Science:

  • Gastroenterology
  • Clinical Chemistry
  • Nutritional Science

Background:

  • Accurate Crohn's disease (CD) activity assessment is challenging, necessitating novel, noninvasive biomarkers.
  • Selenium deficiency is prevalent in CD patients, but its link to disease severity is not well-established.

Purpose of the Study:

  • To investigate the potential of serum selenium concentration as a biomarker for CD severity.
  • To evaluate the correlation between serum selenium levels and various disease activity and nutritional markers in CD patients.

Main Methods:

  • Retrospective study of 135 hospitalized Asian CD patients (aged 18-60).
  • Serum selenium measured by inductively coupled plasma mass spectrometry.
  • Disease severity assessed using endoscopic scores, clinical indices, inflammatory markers, and nutritional status indicators.

Main Results:

  • Serum selenium levels showed a significant inverse association with all evaluated CD activity parameters (P < 0.05).
  • Multivariate analysis confirmed independent correlations between serum selenium and the Simple Endoscopic Score for CD, serum albumin, and serum folic acid (P < 0.05).

Conclusions:

  • Serum selenium concentration is inversely correlated with endoscopic disease severity in Asian CD patients.
  • Serum selenium shows feasibility as an additional biomarker for assessing and monitoring CD activity.
  • Further research considering geographic, sample size, and dietary factors is warranted.