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Updated: Sep 28, 2025

Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells
Published on: April 12, 2021
Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges
Tadao Maeda1, Michiko Mandai1, Sunao Sugita2
1Research Center, Kobe City Eye Hospital, Kobe 6500-047, Japan; Kobe City Eye Hospital, Department of Ophthalmology, Kobe 6500-047, Japan; Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
Abstract:
Stem cell-based therapy for retinal degeneration is transitioning from the research stage to the clinical stage and is being developed as a treatment across the globe. In clinical studies on induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) transplantation, the safety of the technique has started to clarify, and clinical study on further advances such as the long-desired transplantation of iPSC-derived retina to treat retinitis pigmentosa (RP) has begun. Ophthalmologists are now working closely with basic researchers to incorporate new technology areas with a synergy that is anticipated to realize the practical application of stem cell-based therapy for retinal degeneration.
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