Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histological pattern and changes in extracellular matrix in aortic dissections.

H Sariola, T Viljanen, R Luosto

    Journal of Clinical Pathology
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue.

    British journal of cancer·2010
    Same author

    High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytoma.

    Endocrine-related cancer·2009
    Same author

    Non-invasive estimation of hepatic glucose uptake from [18F]FDG PET images using tissue-derived input functions.

    European journal of nuclear medicine and molecular imaging·2009
    Same author

    Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease.

    Journal of neurology, neurosurgery, and psychiatry·2008
    Same author

    Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours.

    Neuropathology and applied neurobiology·2008
    Same author

    E6/E7 oncogenes increase and tumor suppressors decrease the proportion of self-renewing neural progenitor cells.

    Oncogene·2006
    Same journal

    Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

    Journal of clinical pathology·2026
    Same journal

    MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

    Journal of clinical pathology·2026
    Same journal

    Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

    Journal of clinical pathology·2026
    Same journal

    MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

    Journal of clinical pathology·2026
    Same journal

    Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy.

    Journal of clinical pathology·2026
    Same journal

    Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism.

    Journal of clinical pathology·2026
    See all related articles

    Aortic dissection involves defects in type IV collagen and fibronectin within the aortic wall. These extracellular matrix changes, particularly in basement membranes, may play a key role in the condition's development.

    Area of Science:

    • Cardiovascular Biology
    • Connective Tissue Research
    • Pathology

    Background:

    • The extracellular matrix (ECM) is crucial for maintaining aortic wall integrity.
    • Alterations in ECM components are implicated in various aortic diseases.

    Purpose of the Study:

    • To investigate the distribution of key ECM components in aortic dissection.
    • To identify specific ECM defects associated with different aortic pathologies.

    Main Methods:

    • Histological and immunocytochemical analysis of aortic samples from 34 patients.
    • Indirect biotin-avidin peroxidase technique used to detect type IV collagen, fibronectin, and types I and III collagens.

    Main Results:

    • Defects in type IV collagen and fibronectin were observed around medial smooth muscle cells in most dissection cases.

    Related Experiment Videos

  • Basement membrane defects varied in location depending on the specific condition (cystic medial degeneration, medionecrosis, atherosclerosis, aortitis).
  • Interstitial collagens (types I and III) showed no defects in dissecting aortas but were abundant in other conditions.

    • Conclusions:

    • Local changes in medial smooth muscle cell basement membranes are significant in aortic dissection pathogenesis.
    • ECM alterations, particularly type IV collagen and fibronectin, are characteristic of aortic dissection and related conditions.