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Physicochemical Properties and Methods of Analysis of Vildagliptin (Review)
E B Polyakova1, D R Sabirzyanov1,2, N A Prozorova1
1OOO Parma Clinical, Building 16, Prichalnaya Street, 614113 Perm, Russia.
Abstract:
Vildagliptin is an oral agent which is a member of a new class of hypoglycemic drugs, dipeptidylpeptidase-4 (DPP-4) inhibitors. This review presents the physicochemical properties of vildagliptin and assesses analysis methods for its estimation in substances, medicinal formulations, and biological media. These are chromatographic, spectrophotometric, electrochemical and other analysis methods. The material presented may be useful for developing new methods for analysis of medicinal formulations containing vildagliptin. The most widely used method for assay of vildagliptin is HPLC.
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