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08:18
Three-Dimensional Reconstruction of Orbital Fractures
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342
Orbital Inflammation Caused by Aminobisphosphonates.
J Gonzalez Barlatay1, C Pagano Boza1, G V Hernandez Gauna1
1Division of Orbital and Ophthalmic Plastic Surgery, Hospital Italiano de Buenos Aires, Argentina.
Journal of Ophthalmic & Vision Research
|April 4, 2022
Summary
Aminobisphosphonates can cause severe orbital inflammation, often presenting unilaterally with swelling and pain. Early recognition and corticosteroid treatment are crucial for favorable outcomes.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Orbital inflammation is a serious condition.
- Aminobisphosphonates are commonly used for bone-related conditions.
Purpose of the Study:
- To review orbital inflammation secondary to aminobisphosphonate use.
- Analyze demographic data, clinical presentation, and treatment.
Main Methods:
- Narrative literature review.
- Searched Ovid/MEDLINE and COCHRANE databases.
- Included English-language papers.
Main Results:
- Identified 43 cases of orbital inflammation linked to aminobisphosphonates.
- Zoledronate was the most frequently implicated drug.
- Common symptoms include unilateral involvement, eyelid edema, conjunctival congestion, chemosis, pain, motility impairment, proptosis, and blurred vision.
Conclusions:
- Orbital inflammation from aminobisphosphonates is a severe, clinically indistinguishable condition from idiopathic cases.
- Ruling out prior drug exposure is essential.
- Prompt treatment with systemic corticosteroids is vital for a positive prognosis.
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