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Updated: Sep 28, 2025
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Micro-scale Engineering for Cell Biology
Published on: October 1, 2007
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MicroED: conception, practice and future opportunities
Max T B Clabbers1, Anna Shiriaeva1, Tamir Gonen1,2,3
1Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA.
Iucrj
|April 4, 2022
Abstract:
This article documents a keynote seminar presented at the IUCr Congress in Prague, 2021. The cryo-EM method microcrystal electron diffraction is described and put in the context of macromolecular electron crystallography from its origins in 2D crystals of membrane proteins to today's application to 3D crystals a millionth the size of that needed for X-ray crystallography. Milestones in method development and applications are described with an outlook to the future.
