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Novel Insights into the Roles and Mechanisms of GLP-1 Receptor Agonists against Aging-Related Diseases

Wei Peng1, Rui Zhou2, Ze-Fang Sun2

  • 11Department of Gastrointestinal Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.

Aging and Disease
|April 4, 2022
PubMed

Insights

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), used for type 2 diabetes, show potential in delaying aging and treating age-related diseases. Further research is needed to explore their clinical applications in aging.

Area of Science:

  • Gerontology and pharmacology
  • Endocrinology and metabolic diseases

Background:

  • Aging and its associated diseases present significant health challenges.
  • Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are established treatments for type 2 diabetes mellitus (T2DM).
  • GLP-1 RAs exhibit protective effects against key aging factors like oxidative stress, cellular senescence, and chronic inflammation.

Purpose of the Study:

  • To elucidate the mechanisms and protective roles of GLP-1 RAs in the aging process.
  • To explore the potential of GLP-1 RAs in managing and preventing aging-related diseases.
  • To identify research gaps for clinical applications of GLP-1 RAs in aging.

Main Methods:

  • Review of molecular, cellular, and phenotypic mechanisms.
  • Analysis of existing literature on GLP-1 RAs and aging.
  • Identification of therapeutic prospects and clinical research needs.

Main Results:

  • GLP-1 RAs demonstrate multifaceted protective effects relevant to aging.
  • The review provides molecular and cellular insights into GLP-1 RA actions in aging.
  • Novel perspectives on the therapeutic potential of GLP-1 RAs for aging are presented.

Conclusions:

  • GLP-1 RAs hold promise for delaying aging and treating age-related conditions.
  • Further clinical studies are essential to validate the application of GLP-1 RAs in aging.
  • This review establishes a foundation for future research on GLP-1 RAs and aging-related diseases.
Keywords:
GLP-1 receptor agonistsagingaging-related diseasesglucagon-like peptide-1

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