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Side effects of positive pressure ventilation on hepatic function and splanchnic circulation
International Journal of Clinical Monitoring and Computing
|January 1, 1986
Summary
Positive pressure ventilation significantly reduces splanchnic blood flow, impacting liver oxygen supply. These hemodynamic changes can lead to organ dysfunction in the mesenteric bed and liver.
Area of Science:
- Cardiovascular Physiology
- Hepatology
- Critical Care Medicine
Background:
- Positive pressure ventilation (PPV) is a cornerstone of respiratory support in critical care.
- PPV can alter circulatory dynamics, affecting organ perfusion.
- Understanding these effects is crucial for optimizing patient management.
Purpose of the Study:
- To investigate the impact of positive pressure ventilation on splanchnic circulation.
- To elucidate the consequences of these hemodynamic changes on hepatic and mesenteric blood flow.
- To assess the potential for organ dysfunction due to altered blood supply.
Main Methods:
- Hemodynamic monitoring during positive pressure ventilation.
- Assessment of cardiac output distribution.
- Evaluation of splanchnic and hepatic blood flow.
- Analysis of hepatic venous outflow.
Main Results:
- Positive pressure ventilation led to a reduction and redistribution of cardiac output.
- Splanchnic blood flow was decreased, with hepatic blood supply reduction exceeding the fall in cardiac output.
- Oxygen transport to the mesenteric bed and liver was curtailed, alongside impaired hepatic venous outflow.
Conclusions:
- Positive pressure ventilation significantly compromises splanchnic and hepatic perfusion.
- These hemodynamic alterations pose a risk for functional, structural, and metabolic disturbances in organs supplied by the splanchnic circulation.
- Clinical vigilance is warranted to mitigate potential organ damage during PPV.