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Related Experiment Video

Updated: Sep 28, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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US-Elastography With Different Techniques for Thyroid Nodule Characterization: Systematic Review and Meta-analysis.

Vito Cantisani1, Annalisa De Silvestri2, Valeria Scotti2

  • 1Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Frontiers in Oncology
|April 4, 2022
PubMed
Summary

Ultrasound elastography (USE) effectively assesses thyroid nodule malignancy risk. Qualitative and semi-quantitative USE show high diagnostic accuracy, making them valuable for daily clinical use in risk stratification.

Keywords:
USEmeta-analysisreal-time elastographyshear wave elastographystrain elastographythyroid

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Area of Science:

  • Radiology and Imaging
  • Oncology
  • Endocrinology

Background:

  • Thyroid nodules are common in adults, with a significant increase in thyroid cancer incidence.
  • Accurate risk stratification of thyroid nodules is crucial for patient management.

Approach:

  • A systematic review and meta-analysis evaluated diagnostic performance of ultrasound elastography (USE) for thyroid nodule malignancy risk.
  • PubMed and Embase databases were searched (January 2011–July 2021) for relevant studies.
  • Diagnostic accuracy metrics (sensitivity, specificity, AUC) were calculated for qualitative, semi-quantitative, and quantitative USE.

Key Points:

  • 72 studies involving 13,505 patients and 14,015 nodules were analyzed.
  • Pooled results showed high diagnostic accuracy for qualitative (AUC 0.89) and semi-quantitative USE (AUC 0.93).
  • Qualitative and semi-quantitative USE demonstrated superior diagnostic performance compared to quantitative USE.

Conclusions:

  • Ultrasound elastography is a valuable imaging tool for characterizing thyroid nodules.
  • USE can be routinely implemented for daily thyroid nodule malignancy risk stratification, aligning with current guidelines.