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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
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Epigenetics in prostate cancer treatment
Katelyn Jones1, Yanquan Zhang1, Yifan Kong1
1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA.
Journal of Translational Genetics and Genomics
|April 4, 2022
Summary
This review discusses epigenetic modifications in prostate cancer (PCa) development and resistance. Targeting these epigenetic changes shows promise for novel PCa therapies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Prostate cancer (PCa) is a leading malignancy in men, with limited treatment options upon progression.
- Epigenetic alterations, including DNA methylation and histone modifications, are key drivers in PCa development and advancement.
Purpose of the Study:
- To review the role of epigenetic modifications in prostate cancer development and progression to resistant forms.
- To introduce therapeutic strategies targeting epigenetic alterations for PCa treatment.
Main Methods:
- Literature review of studies on epigenetic modifications in prostate cancer.
- Analysis of pre-clinical and clinical data on epigenetic therapies for PCa.
Main Results:
- Epigenetic alterations are crucial in PCa initiation and progression.
- Targeting epigenetic enzymes and regulatory proteins shows efficacy in regulating cancer cell growth.
- Several epigenetic drugs have advanced to clinical trials for PCa treatment.
Conclusions:
- Epigenetic modifications play a significant role in prostate cancer.
- Targeting epigenetic pathways represents a promising therapeutic strategy for advanced and resistant prostate cancer.
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