Related Experiment Video
Updated: Sep 28, 2025
09:43
Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
Published on: August 10, 2015
16.1K
d-Serine Mediates Cellular Proliferation for Kidney Remodeling
Atsushi Hesaka1,2,3, Yusuke Tsukamoto1,2, Shigeyuki Nada4
1KAGAMI Project, National Institutes of Biomedical Innovation, Health and Nutrition.
Kidney360
|April 4, 2022
Summary
D-serine, a previously undetected serine enantiomer, impacts kidney remodeling. This study reveals its physiological role in kidney function beyond its biomarker status.
Area of Science:
- Biochemistry
- Physiology
- Nephrology
Background:
- D-serine, an enantiomer of serine, is a biomarker for kidney function and disease.
- The physiological roles of D-serine have remained largely uncharacterized.
Purpose of the Study:
- To investigate the physiological dynamics and functions of D-serine in the kidney.
- To explore D-serine's impact on kidney remodeling and cellular processes.
Main Methods:
- D-serine levels were measured in human kidney donors using HPLC.
- Autoradiographic studies in mice assessed D-serine distribution.
- Gene expression and metabolic studies in nephrectomized mice and cell models elucidated D-serine's effects.
Main Results:
- Unilateral nephrectomy in humans led to decreased urinary D-serine excretion and increased blood levels.
- In mice, injected D-serine rapidly accumulated in the kidney, indicating it as a primary target organ.
- Low-dose D-serine promoted remnant kidney enlargement in mice by activating cell cycle and mTOR-related pathways for tissue remodeling.
Conclusions:
- D-serine is a physiological molecule that actively promotes kidney remodeling.
- Beyond its established role as a biomarker, D-serine exerts a direct physiological influence on kidney function.
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