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Abnormalities in Cardiac Structure and Function among Individuals with CKD: The COMBINE Trial
Ann A Wang1, Xuan Cai2, Anand Srivastava2,3
1Graduate Medical Education, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Kidney360
|April 4, 2022
Summary
Individuals with chronic kidney disease (CKD) show cardiac abnormalities. Higher albuminuria is linked to diastolic dysfunction in CKD patients, regardless of existing cardiovascular disease (CVD).
Area of Science:
- Nephrology
- Cardiology
- Biomarkers
Background:
- Chronic kidney disease (CKD) significantly increases the risk of cardiovascular disease (CVD).
- Subclinical CVD in CKD patients can be detected using cardiac magnetic resonance imaging (cMRI).
Purpose of the Study:
- To compare cMRI parameters between CKD patients and healthy controls.
- To investigate associations between CKD biomarkers and cMRI findings.
Main Methods:
- cMRI was performed on 140 individuals with CKD stages 3b-4 and 24 healthy volunteers.
- Associations between eGFR, UACR, phosphate, FGF23, PTH, and cMRI parameters were analyzed cross-sectionally and longitudinally.
Main Results:
- CKD patients exhibited lower mitral valve E/A ratio compared to controls.
- Higher urine albumin-creatinine ratio (UACR) was independently associated with lower mitral valve E/A ratio in CKD patients.
- No significant associations were found between eGFR, phosphate, FGF23, PTH, and cMRI parameters.
Conclusions:
- CKD stages 3b-4 are associated with cardiac structural and functional abnormalities detected by cMRI.
- Albuminuria is an independent predictor of diastolic dysfunction in CKD patients.
- Albuminuria did not predict changes in cMRI parameters over 12 months.
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