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Updated: Sep 28, 2025

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection
Lisa H F McGary1,2,3, Santosha A Vardhana3,4
1Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, New York.
Summary:
Fahrner and colleagues investigated the immune response of patients with cancer and cancer-free individuals to SARS-CoV-2 and found that a propensity toward an IL5-predominant Th2/Tc2 response was predictive of susceptibility to infection. The results of this study also suggest that a cellular response against the Spike 1 protein receptor binding domain (S1-RBD) region of the SARS-CoV-2 proteome contributes to protection and that mutations in this region may drive viral evolution and immune escape. See related article by Fahrner et al., p. 958 (8).
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